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Leading titanium dioxide manufacturers have started to explore alternative synthesis routes that minimize waste and reduce energy consumption. For instance, some have turned to the sol-gel process, which allows for the production of nanoparticles at lower temperatures with better control over the particle size distribution. Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material use Others are looking into recycling waste streams from the manufacturing process to recover titanium compounds, thus closing the loop on material usetitanium dioxid manufacturer.

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Drobne et al. used the terrestrial arthropod Porcellio scaber as a test organism for determining the cytotoxic effect of TiO2 NPs (anatase). The animals were exposed to TiO2 NPs of two different sizes (25 nm and 75 nm) in the concentration range 10–1000 μg TiO2/g dry food for 3 to 14 days. No adverse effects, such as mortality, body weight changes or reduced feeding, were observed. In fact, quite the opposite, an enhanced feeding rate, food absorption efficiency and increase in catalase activity were observed. The intensity of these responses appeared to be time- but not dose-dependent. It should also be noted that the concentrations tested in this study were much higher than the predicted concentration (4.8 μg/g soil) at high emission scenario of nano-sized TiO2. Using the same test organism another group showed that exposure to TiO2 NPs induced destabilization of cell membrane in the epithelium of digestive glands isolated from exposed animals. They also showed that this effect can be observed after just 30 minutes of exposure.

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